A scientist performing illegal stem cell research is trying to find a cure for cancer. After the transfer of shark cells is made into a human test subject, the ill man gets well again and it looks like the treatment was a success. But the experiment goes wrong, and the man transforms into monster: half-shark & half-human. But the scientist knows how to use this to his advantage. He has invited some of his old pals to the island and is hoping to take revenge on them with his new creature. But do they have any tricks up their sleeve?

　　蝙蝠侠与罗宾突然收到一个情报，得悉一名大人物正身陷险境，他们正欲展开拯救行动。岂料这原来是小丑、猫女、企鹅、谜语人四名超级份子合作布下的局，他们打算利用仪器把全人类变做灰尘，继而统治全世界！全人类的性命悬于一线，蝙蝠侠与罗宾决定伸张正义，儆恶惩奸，击退坏份子。然而面对天下最聪明的四大坏蛋连手，要粉碎这计谋真是谈何容易……